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www.11rba.com_申博下载中心

文章来源:SEO    发布时间:2019-10-15 18:24:49  【字号:      】

www.11rba.com_申博下载中心Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.

Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.

Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.

Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.Michelle Obama's memoir 'Becoming' out, an instant hit#标题分割#Anewmemoirtitled"Becoming"byMichelleObamawasoutTuesday,inwhichtheformerU.S.firstladyrevealedherfamilylife,somethoughtsaboutherhusband'ssuccessorDonaldTrump,aswellasherreflectionsonvariouschallengesinherpersonallife.ThebookisalreadyNo.1amongbestsellersonAmazon.HercommentsaboutTrumpincludeaccusationsthathis"birther"conspiracyputherfamilyindangerandthatshe"stoppedeventryingtosmile"atTrump'sinaugurationceremonyonJan.20,2017."Ihadtosharemyvulnerabilityandalsolearntolovedifferently,"shewroteaboutsomebumpsduringhermarriagewithBarackObama,includingaperiodshefeltfrustrationsoverbeing"aworkingfull-timemotherwithahalf-timespouse."ThecoupleonceattendedmarriagecounsellingandMichellemiscarriedbeforegivingbirthtohertwodaughtersthroughinvitrofertilization,accordingtoexcerptsofthebookrevealedbylocalmediareports.MichelleadministeredtheIVFshotsherselfwhileherhusbandwasawayservinginstatelegislature.Localmediasaidthecandidtalkhelpsdispellingthetaboosaroundsuchstruggles.Shealsosaidofherdiscomfortofbeingahyperaccomplishedwomanonlyrecognizedthroughherconnectiontoapowerfulman,anddeepfrustrationofbeingmisunderstoodandlabelledasan"angryblackwoman.""Ihatewhenpeoplewhoareinthepubliceye--andevenseekthepubliceye--wanttostepbackandsay,'Well,I'mnotarolemodel.Idon'twantthatresponsibility.'"sheexplainedinaninterviewwithOprahWinfreywhysherevealedsuchdetailsofherprivatelifeinthenewbook."Toolate.Youare.Youngpeoplearelookingatyou.AndIdon'twantyoungpeopletolookatmehereandnowandthink:Well,sheneverhaditrough,sheneverhadchallenges,sheneverhadfears."saidtheformerfirstlady.MichellesignedajointbookdealwithBarackforareported65-million-dollardealsoonaftertheylefttheWhiteHouselastyear.

多发性硬化症有望康复?“唤醒”此蛋白是关键#标题分割#  少突细胞是修复髓鞘的“工程队”  据了解,我们大脑、脊髓以及四肢的神经系统中,大直径神经轴突基本都被髓鞘包裹着,神经信号就在髓鞘的帮助下进行快速传导。髓鞘的缺失会减慢中枢神经系统信息的传递,并影响轴突的生存,临床上引起如多发性硬化症、视神经脊髓炎等疾病。  多发性硬化症作为罕见病的一种,好发于青壮年,患者因中枢神经系统的髓鞘遭到破坏,会出现肢体无力、感觉异常、视神经炎等症状。我国多发性硬化症患者确诊周期长,47%的患者不能被立即确诊,38%患者被误诊为其他疾病,全国预计约有3万名患者。现行的治疗方式多以激素配合免疫抑制剂为主,但只能使病情得到缓解,并无有效根治措施,且会带来一定的副作用。  张亮告诉科技日报记者,在我们大脑内,有一支专门用于修建和修复“髓鞘”这种“高速公路”的“工程队”——少突细胞,这种细胞只有成熟以后,才能完成它的职责。而在脱髓鞘相关疾病的患者体内,尽管发现有少突细胞这种“工程队”的存在,但它们似乎并没有进入工作状态,不能快速有效地修复“高速公路”上的各种破损,也就是髓鞘不能被重新生成,轴突无法被重新包裹。因此,大脑发出的神经指令堵在“高速公路”上,无法到达目的地去指挥各种器官和肌肉的运动。  如何让少突细胞变得成熟,进入工作状态,再生出髓鞘?这在国际上仍是一个尚未解决的重要生物医学问题,也是帮助多发性硬化症、视神经脊髓炎等相关患者早日康复的关键。  找到“唤醒”少突细胞的关键蛋白  核孔蛋白是核孔复合体的组成部分,可调节细胞核与细胞内物质的交流沟通。已经发现的核孔蛋白大约有30种,除了组成核孔复合体以外,它们“身兼数职”,其中有几个能帮助调节基因何时何地被转化为蛋白质。  张亮团队在研究中首先发现了一种核孔蛋白——Seh1,该蛋白在少突细胞分化过程中特异性地表达量会增加,而且在少突细胞中人为增加该蛋白的表达量,可以促进细胞的分化和髓鞘的生成。  “为了验证该结论,我们构建了多种小鼠模型,在实验中发现,该核孔蛋白的缺失会造成小鼠震颤、行动不稳等一系列类似脱髓鞘的症状。”张亮介绍说,在人为破坏小鼠的髓鞘系统后,缺少这种核孔蛋白的突变小鼠无法快速恢复髓鞘的再生。同时,人为地增加这种蛋白的含量,却能够促进突变小鼠少突细胞的成熟和髓鞘的生成。  该团队进一步采用分子生物学手段研究发现,核孔蛋白能够在核孔复合体周围“招募”转录因子“Olig2”和染色质重塑蛋白“Brd7”,构建一个促进少突细胞分化的转录微环境,帮助少突细胞更快地变得成熟,从而生成髓鞘。  这项研究在国际上首次发现了核孔蛋白Seh1在髓鞘再生中的生理功能,为利用核孔蛋白作为靶点设计小分子药物提供了科学思路,对多发性硬化症、视神经脊髓炎等疾病的治疗有着重要的参考意义。该研究工作还得到了厦门大学莫玮教授、美国西南医学中心丰托拉教授的大力支持。多发性硬化症有望康复?“唤醒”此蛋白是关键#标题分割#  少突细胞是修复髓鞘的“工程队”  据了解,我们大脑、脊髓以及四肢的神经系统中,大直径神经轴突基本都被髓鞘包裹着,神经信号就在髓鞘的帮助下进行快速传导。髓鞘的缺失会减慢中枢神经系统信息的传递,并影响轴突的生存,临床上引起如多发性硬化症、视神经脊髓炎等疾病。  多发性硬化症作为罕见病的一种,好发于青壮年,患者因中枢神经系统的髓鞘遭到破坏,会出现肢体无力、感觉异常、视神经炎等症状。我国多发性硬化症患者确诊周期长,47%的患者不能被立即确诊,38%患者被误诊为其他疾病,全国预计约有3万名患者。现行的治疗方式多以激素配合免疫抑制剂为主,但只能使病情得到缓解,并无有效根治措施,且会带来一定的副作用。  张亮告诉科技日报记者,在我们大脑内,有一支专门用于修建和修复“髓鞘”这种“高速公路”的“工程队”——少突细胞,这种细胞只有成熟以后,才能完成它的职责。而在脱髓鞘相关疾病的患者体内,尽管发现有少突细胞这种“工程队”的存在,但它们似乎并没有进入工作状态,不能快速有效地修复“高速公路”上的各种破损,也就是髓鞘不能被重新生成,轴突无法被重新包裹。因此,大脑发出的神经指令堵在“高速公路”上,无法到达目的地去指挥各种器官和肌肉的运动。  如何让少突细胞变得成熟,进入工作状态,再生出髓鞘?这在国际上仍是一个尚未解决的重要生物医学问题,也是帮助多发性硬化症、视神经脊髓炎等相关患者早日康复的关键。  找到“唤醒”少突细胞的关键蛋白  核孔蛋白是核孔复合体的组成部分,可调节细胞核与细胞内物质的交流沟通。已经发现的核孔蛋白大约有30种,除了组成核孔复合体以外,它们“身兼数职”,其中有几个能帮助调节基因何时何地被转化为蛋白质。  张亮团队在研究中首先发现了一种核孔蛋白——Seh1,该蛋白在少突细胞分化过程中特异性地表达量会增加,而且在少突细胞中人为增加该蛋白的表达量,可以促进细胞的分化和髓鞘的生成。  “为了验证该结论,我们构建了多种小鼠模型,在实验中发现,该核孔蛋白的缺失会造成小鼠震颤、行动不稳等一系列类似脱髓鞘的症状。”张亮介绍说,在人为破坏小鼠的髓鞘系统后,缺少这种核孔蛋白的突变小鼠无法快速恢复髓鞘的再生。同时,人为地增加这种蛋白的含量,却能够促进突变小鼠少突细胞的成熟和髓鞘的生成。  该团队进一步采用分子生物学手段研究发现,核孔蛋白能够在核孔复合体周围“招募”转录因子“Olig2”和染色质重塑蛋白“Brd7”,构建一个促进少突细胞分化的转录微环境,帮助少突细胞更快地变得成熟,从而生成髓鞘。  这项研究在国际上首次发现了核孔蛋白Seh1在髓鞘再生中的生理功能,为利用核孔蛋白作为靶点设计小分子药物提供了科学思路,对多发性硬化症、视神经脊髓炎等疾病的治疗有着重要的参考意义。该研究工作还得到了厦门大学莫玮教授、美国西南医学中心丰托拉教授的大力支持。




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